Non-pathogenic Anti-Desmoglein 3 IgG Autoantibodies in Fogo Selvagem
نویسندگان
چکیده
منابع مشابه
Analysis of Anti-desmoglein 1 Autoantibodies in 68 Healthy Mother/Neonate Pairs from a Highly Endemic Region of Fogo Selvagem in Brazil
OBJECTIVES Fogo Selvagem (FS) in Limao Verde (LV), Brazil shows clinical and histological features of pemphigus foliaceus (PF) and shares pathogenic IgG4 anti-desmoglein 1 (Dsg1) autoantibodies. Previously, our group reported that mothers with active FS deliver babies with normal skin and low/negative titers of IgG4 autoantibodies by indirect immunofluorescence. It was postulated that maternal ...
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It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS). Isolated reports have shown that in certain patients with these diseases, autoantibodies against other desmosomal cadherins and E-cadherin may also be present. The goal of this inves...
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Pemphigus foliaceus (PF) is characterized by acantholysis determined by IgG4 binding to desmoglein I, a 160-kDa desmosomal glycoprotein. To investigate the immunopathological aspects of Brazilian PF, we determined levels of serum cytokines in patients with PF. Twenty-five patients with PF and a control group consisting of 10 healthy individuals were studied. Serum IL-2, IL-4, IL-5, IL-10, IL-12...
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* Gastroenterology and Hepatology Service, Federal University of Goiás Medical School, Goiânia, GO, Brazil. ** Virology Laboratory, Tropical Pathology and Public Heath Institute, Federal University of Goiás, Goiânia, GO. *** Innogenetics, Ghent, Belgium. Forum on Prevalence of Virus C Infection in Brazil. XVI Brazilian Congress of Hepatology, October, 1997; Pousada do Rio Quente, GO, Brazil. Ad...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2006
ISSN: 0022-202X
DOI: 10.1038/sj.jid.5700457